On the lagging strand, the Okazaki fragments are synthesized sequentially, with those nearest the fork being the most recently made.The synthesis of one of many DNA fragments on the lagging strandThe synthesis of one of many DNA fragments on the lagging strand. Because both daughter DNA strands are polymerized in the 5’ to 3'direction, the DNA synthesized on the lagging strand must be made initially as a series of short DNA molecules, called Okazaki fragments. The original strands therefore remain intact through many cell generationsThe structure of a DNA replication forkThe structure of a DNA replication fork. In a round of replication, each of the two strands of DNA is used as a template for the formation of a complementary DNA strand. As shown, base-pairing between an incoming deoxyribonucleoside triphosphate and an existing strand of DNA (the template strand) guides the formation of the new strand of DNA and causes it to have a complementary nucleotide sequence.Review: Replication The semiconservative nature of DNA replication. The addition of a deoxyribonucleotide to the 3' end of a polynucleotide chain (the primer strand) is the fundamental reaction by which DNA is synthesized.
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